TY - JOUR T1 - Dipyrone as pre-emptive measure in postoperative analgesia after tonsillectomy in children: a systematic review JO - Brazilian Journal of Otorhinolaryngology (English Edition) T2 - AU - Stangler,Maira Isis S. AU - Lubianca,João Pedro Neves AU - Lubianca,Jaqueline Neves AU - Lubianca Neto,José Faibes SN - 18088694 M3 - 10.1016/j.bjorl.2020.12.005 DO - 10.1016/j.bjorl.2020.12.005 UR - http://www.bjorl.org.br/en-dipyrone-as-pre-emptive-measure-in-articulo-S1808869420302457 AB - IntroductionTonsillectomy is the 2nd most common outpatient surgery performed on children in the United States of America. Its main complication is pain, which varies in intensity from moderate to severe. Dipyrone is one of the most widely used painkillers in the postoperative period in children. Its use, however, is controversial in the literature, to the point that it is banned in many countries due to its potential severe adverse effects. Because of this controversy, reviewing the analgesic use of dipyrone in the postoperative period of tonsillectomy in children is essential. ObjectiveThe aim of this study was to review the analgesic use of dipyrone in the postoperative period of tonsillectomy in children. MethodsSystematic review of the literature, involving an evaluation of the quality of articles in the databases MEDLINE/Pubmed, EMBASE and Virtual Health Library, selected with a preestablished search strategy. Only studies with a randomised clinical trial design evaluating the use of dipyrone in the postoperative period of tonsillectomy in children were included. Results and conclusionOnly 2 randomised clinical trials were found. Both compared dipyrone, paracetamol, and placebo. We were unable to carry out a metanalysis because the studies were too heterogenous (dipyrone was used as pre-emptive analgesic in one and only postoperatively in another). The analgesic effect of dipyrone, measured by validated pain scales in childhood, was shown to be superior to placebo and similar to paracetamol. It appears that dipyrone exhibits a profile suitable for use in children. However, the scarcity of randomised clinical trials evaluating its analgesic effect in this age group leads to the conclusion that more well-designed studies are still needed to establish the role of dipyrone in the postoperative period of tonsillectomy in children. ER -