TY - JOUR T1 - Outcomes of endoscopic and open resection of sinonasal malignancies: a systematic review and meta-analysis JO - Brazilian Journal of Otorhinolaryngology (English Edition) T2 - AU - Jiang,Sijie AU - Fan,Ruohao AU - Zhang,Hua AU - Jiang,Weihong AU - Xie,Zhihai SN - 18088694 M3 - 10.1016/j.bjorl.2021.06.004 DO - 10.1016/j.bjorl.2021.06.004 UR - http://www.bjorl.org.br/en-outcomes-endoscopic-open-resection-sinonasal-articulo-S1808869421001270 AB - ObjectiveTo compare the efficacy of endoscopic and open resection of sinonasal malignancies. MethodsThe search was performed using PubMed (1950–2020), Embase (1974–2020), the Cochrane library, and the website clinicaltrials.gov. The hazard ratio, HR, 95% confidence interval, CI, of the rates of overall survival and disease-free survival and the demographic characteristics of the included studies were extracted and analyzed. Pooled analysis was conducted with the studies’ individual patient data, using log-rank test, Kaplan–Meier survival, and Cox regression analysis. ResultsOf 1939 articles retrieved, 23 articles were included. Overall, 1373 cases were incorporated into the final analysis, 653 (47.56%) of which underwent the surgery through an endoscopic approach, whereas 720 (52.44%) cases utilized the open approach. The overall survival was comparable between endoscopic and open resection (HR = 0.84 [95% CI: 0.65–1.07], p = 0.16; random effects analysis). Pooled analysis with Cox regression revealed signifcant differences in overall survival (HR = 0.568 [95%CI:0.380-0.849], p = 0.006) and disease-free survival (HR = 0.628 [95%CI:0.424-0.929], p = 0.02) between endoscopic and open approaches. ConclusionThe aggregated evidence suggests the survival outcome of endoscopic resection is comparable or greater than that of open resection of sinonasal malignancies. ER -