TY - JOUR T1 - Treatment outcomes of alternating chemoradiotherapy for nasopharyngeal carcinoma: a single-center safety and efficacy study JO - Brazilian Journal of Otorhinolaryngology (English Edition) T2 - AU - Ohara,Kenzo AU - Takahara,Miki AU - Kumai,Takumi AU - Yamashina,Masaaki AU - Kishibe,Kan AU - Katada,Akihiro AU - Hayashi,Tatsuya SN - 18088694 M3 - 10.1016/j.bjorl.2022.12.004 DO - 10.1016/j.bjorl.2022.12.004 UR - http://www.bjorl.org.br/en-treatment-outcomes-alternating-chemoradiotherapy-for-articulo-S1808869422002464 AB - ObjectiveTo evaluate the efficacy and safety of Alternating Chemoradiotherapy (ACRT) using cisplatin and 5-Fluorouracil (5-FU) in patients with nasopharyngeal carcinoma. MethodsThis was a retrospective study in which patients’ clinical records were reviewed to identify patients with a new diagnosis of nasopharyngeal carcinoma at our institution between January 2005 and January 2019. Thirty-seven eligible patients were identified; of these, the clinical details of 27 patients treated with ACRT were evaluated. Patient outcomes, including overall survival and progression-free survival, and adverse events were assessed. ResultsOf these initial 37 patients, 1, 10, 13, 10, and 3 were staged as I, II, III, IVA, and IVB, respectively, as defined by the 8th edition of the TNM classification system. Twenty-seven patients received ACRT comprising sequential administration of chemotherapy, radiotherapy (wide field), chemotherapy, radiotherapy (shrinking field), and chemotherapy. The 5-year overall survival and progression-free survival rates were 83.7% and 88.9%, respectively. Treatment compliance was 93%, which is comparable to that of previous reports. ConclusionACRT using cisplating and 5-fluorouracil was well tolerated with acceptable efficacy. Level of EvidenceIVa ER -