Journal Information
Vol. 90. Issue 4. (In progress)
(July - August 2024)
This issue is in progress but contains articles that are final and fully citable.
Original articles
NKX2-1 gene is targeted by H19 lncRNA and is found to be overexpressed in benign nodular goiter tissues
Seyed-Morteza Javadirad

  • NKX2-1 gene is an emerging target for H19 lncRNA.

  • Binding site of H19 with NKX2-1 overlaps with has-miR-1827.

  • Increased expression of NKX2-1 observed in benign nodular goiter.

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Efficacy of the posterior nasal nerve resection combined with hormone transnasal nebulization on difficult-to-treat rhinosinusitis: a retrospective analysis
Xin-ke Wang, Qi-ling Zheng, Jia-ning Sun

  • PNN resection & hormone transnasal nebulization shows good efficacy on DTRS.

  • Combination can relieve the symptoms of DTRS patients, reduce adverse reactions.

  • The combination deserves a promotion in clinical practice.

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Cochlear implantation outcomes in children with multiple disabilities: a topic that’s worth revisiting
Goh Bee-See, Nur Af’Idah Mohd Zulkefli, Asma Abdullah, Cila Umat, Norazlin Kamal Nor, Juriza Ismail, Stephen J. O’Leary

  • Hearing loss children with multiple disabilities benefits from cochlear implantation.

  • Communications improved with increasing duration of device usage.

  • Cochlear implant is beneficial in reducing family’s stress level.

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Chronic rhinosinusitis possibly associated with decreased lung function in chronic cough patients
Pengfei Zhao, Shin Kariya, Takaya Higaki, Seiichiro Makihara, Toru Rikimaru, Mitsuhiro Okano, Mizuo Ando

  • The chronic rhinosinusitis patients with chronic cough had significant obstructive lung function.

  • The SNOT score is high in chronic cough patients with chronic rhinosinusitis.

  • The lower airway examination is important in chronic cough patients.

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Clinical experience of an adhesive bone conduction hearing system in children with congenital single-sided deafness
Yujie Liu, Wenxi Qiu, Lin Yang, Yuan Wang, Jikai Zhu, Mengshuang Lv, Shouqin Zhao

  • Adhesive bone conduction device elicits improvement in speech perception.

  • Adhesive bone conduction do not improve sound localisation abilities.

  • Adhesive bone conduction is useful to children with single-sided deafness.

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Degree of swallowing impairment in the elderly: clinical and instrumental assessment
Tatiane Totta Salgado, Cris Magna dos Santos Oliveira, Marina Gatti, Roberta Gonçalves da Silva, Heitor Marques Honório, Giédre Berretin-Felix

  • Elderly presented moderate swallowing impairment for consistencies.

  • There was no difference between clinical and instrumental evaluation.

  • The assessment of swallowing in the elderly must consider physiological changes.

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Postoperative complications in cochlear implant surgery and their possible risk factors
Vanessa Ribeiro Orlando, Oswaldo Laércio Mendonça Cruz

  • Minor complications related with vestibular system were more common.

  • Major complications: changes of wound, device failure and electrode extrusion.

  • Children with a mean age of 19.3-months are more susceptible to infections.

  • There was no correlation between advanced age and higher complication rates.

  • Age should not be an exclusion factor.

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Functional and esthetic outcomes of functional rhinoplasty for internal nasal valve dysfunction in Asian patients
Hahn Jin Jung, Min Woo Park, Woo Sub Shim, Jee Hye Wee
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Endoscopic thyroidectomy via chest-collarbone approach versus conventional open thyroidectomy: a retrospective comparative study
Yuming Lou, Lutong Liu, Miaomiao Jin, Bifei Fu, Chaoyang Xu, Xiaofeng Lu

  • Endoscopic thyroidectomy through chest-collarbone approach is safe and feasible.

  • Chest-collarbone endoscopic thyroid surgery improves in a good cosmetic outcome.

  • Preoperative evaluation of nodule size and nature affects the success rate of surgery.

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Comprehensive analysis of the immune implication of EPHX4 gene in laryngeal squamous cell carcinoma
Nimei Shen, Gang Gao, Xinhong Lu, Jiaxin Jin, Liwei Lin, Maohua Qian, Yang Qin

  • The expression level of EPHX4 was higher in HNSC patients’ tissues.

  • EPHX4 expression is closely associated with the immunity of HNSC.

  • EPHX4 promotes HNSC cells proliferation, colony formation and invasion.

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Voice handicap and voice-related quality of life in COVID-19 patients
Lourival Mendes Bueno, Hugo Valter Lisboa Ramos, Claudiney Cândido Costa, Wilder Alves, Leandro Castro Velasco, Noemi Grigoleto De Biase

  • Lung impairment due to COVID-19 increases the voice handicap index score.

  • The voice-related quality of life score is reduced in these patients.

  • There is a correlation between pulmonary function and the changes in voice.

  • Video laryngoscopy did not identify any laryngeal changes in these patients.

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Traditional and non-traditional lipid parameters as risk factors for sudden sensorineural hearing loss
Xiaoyan Chen, Zhong Zheng, Ximeng Liu, Jianuo Huang, Daoyu Xie, Yanmei Feng

  • SSNHL patients had a higher risk of concomitant hypertension and elevated atherosclerogenic lipid levels.

  • APOB, APOE, and LCI were identified as independent risk factors.

  • Certain lipids showed a positive linear correlation with hearing loss.

  • When TC was in borderline high range, the treatment effect was the best.

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Post-extubation laryngitis in children: diagnosis, management and follow-up
Elaine Costa, Débora Bressan Pazinatto, Luciahelena Prata Trevisan, Rebecca Maunsell

  • Post-extubation laryngitis was confirmed in the majority of suspected cases.

  • Bedside nasopharyngolaryngoscopy assisted, but over half required microlaryngoscopy.

  • Laryngeal stenosis is associated with lesion severity and extubation failures.

  • Close follow-up after discharge prevented any additional tracheostomies.

  • Prognosis is influenced by comorbidities, lesion severity, and tracheostomy.

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Non-invasive treatments improve patient outcomes in chronic tinnitus: a systematic review and network meta-analysis
Tingting Lu, Qingxin Wang, Ziyan Gu, Zefang Li, Zhaojun Yan

  • We searched PubMed, Embase and Cochrane Library databases.

  • This study included 22 randomized controlled trials with a total of 2354 patients.

  • Acoustic therapy combined with cognitive behavior can treat chronic tinnitus.

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Review articles
Non-antibiotic antimicrobial agents for chronic rhinosinusitis: a narrative review
Joao Vitor Bizinoto Caetano, Fabiana Cardoso Pereira Valera, Wilma T. Anselmo-Lima, Edwin Tamashiro

  • Non-antibiotic antimicrobial therapies offer potential alternatives in CRS patients.

  • Most non-antibiotic antimicrobial therapies did not show important side effects.

  • The majority of studies reviewed have low level of evidence.

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Case reports
Ectopic cervical thymic cyst with thyroglossal duct cyst
Weiyao Chen, Juxing Sun, Yanqiu Zhou, Mengyin Li, Shaohua Wang, Xinxin Yang, Xiaoyu Li
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Neuroendocrine adenoma of middle ear: a case report and endoscopic approach
Nicolau Moreira Abrahão, Guilherma Correa Guimarães, Jonas Belchior Tamanini, Sofia Fontes de Oliva Costa, Pedro Juliano de Mesquita Ferreira, Vagner Antônio Rodrigues da Silva, Arthur Menino Castilho
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Wound management for post-laryngeal transplant pharyngeal fistula: a case report
Jiahui Fan, Zheng Jiang, Mailudan Ainiwaer, Rong Yu, Dengying Gu, Huiling Zhao, Fei Chen
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Letters to the editor
Ultrasonography in Bell’s palsy: the elephant in the room
Ahmad J. Abdulsalam, Ameerah Alsaqobi, Murat Kara
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Brazilian Journal of Otorhinolaryngology (English Edition)
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