Journal Information
Vol. 90. Issue 1.
(January - February 2024)
The new frontiers of learning in otorhinolaryngology: a reflection about challenges and advances
Sofia Oliva-Costa
Braz J Otorhinolaryngol. 2024;90:101370
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Original articles
Evaluation of sinonasal-related quality of life of 49 patients undergoing endoscopic skull base surgery
Yijie Zhong, Zeyi Deng, Hailing Chen, Qianhui Qiu
Braz J Otorhinolaryngol. 2024;90:101337

  • Only a small part of patients suffers from ENS after endoscopic skull base surgery.

  • Patients undergoing ESBS were likely to suffer nasal problems and sleep disorders.

  • Patients who had received radiotherapy have a worse QoL.

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Diagnostic accuracy of the video otoscope in tympanic membrane perforation
Leonardo Resende de Sousa, Guilherme Adam Fraga, Igor Souza Pessoa da Costa, Ana Claudia Ferreira de Almeida, Tyuana Sandim da Silveira Sassi, Luiz Fernando Manzoni Lourençone
Braz J Otorhinolaryngol. 2024;90:101336

  • 352 tympanic membranes were analyzed.

  • 7.7% prevalence of tympanic membrane perforation.

  • Sensitivity of 85.2%, specificity of 98.1% and accuracy of 97.1%.

  • 53.4% of the participants considered the video otoscope as the best method.

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Accessibility to manage the obstructive sleep apnea within the Brazilian Unified Health System
Douglas Inomata Cardoso da Silva, Camila de Castro Corrêa, Jefferson Luis de Barros, Antonio Carlos Marão, Silke Anna Theresa Weber
Braz J Otorhinolaryngol. 2024;90:101338

  • A follow-up of the journey of the individual with OSA was carried out.

  • 64.1% of the participants had still not used CPAP or had given up on therapy.

  • Epidemiological and polysomnographic factors did not interfere with the use of CPAP.

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White noise effect on listening effort among patients with chronic tinnitus and normal hearing thresholds
Jeanne Oiticica, Laura G.E. Vasconcelos, Mirella B. Horiuti
Braz J Otorhinolaryngol. 2024;90:101340

  • White noise improved high working memory in 68% of tinnitus patients.

  • White noise reduced high working memory in 8% of tinnitus patients.

  • White noise had no effect in high working memory in 24% of tinnitus patients.

  • White noise could release of cognitive resources and reduce auditory effort.

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Nasopharyngeal carcinoma derived exosomes regulate the proliferation and migration of nasopharyngeal carcinoma cells by mediating the miR-99a-5p BAZ2A axis
Xiao-jun Zhou, Hang-min Xu, Guo-sen Huang, Bao-rui Lin
Braz J Otorhinolaryngol. 2024;90:101343

  • MiR-99a-5p was the most significant differentially expressed gene in exosomes.

  • The proliferation and migration of NPC cells were extremely facilitated by exosomes.

  • NPC derived exosomes facilitated the proliferation and migration of NPC.

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Elective parotidectomy and neck dissection are not beneficial in cutaneous squamous cell carcinoma of the head
Zuzana Horakova, Ivo Starek, Richard Salzman
Braz J Otorhinolaryngol. 2024;90:101352

  • Metastases in cutaneous spinalioma significantly reduce the prognosis.

  • Tumor parameters increasing the risk of their incidence are known.

  • Elective parotidectomies were performed for high-risk skin head tumors.

  • Occult metastases were not found in any of the patients.

  • Elective parotidectomy is not beneficial even for high-risk tumors.

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Translation and cultural adaptation of “Glasgow Children’s Benefit Inventory” into Brazilian Portuguese
Caroline Catherine Lacerda Elias, Adriane Ribeiro Teixeira, Maria Eduarda Claro de Souza, Letícia Petersen Schmidt Rosito, Sady Selaimen da Costa
Braz J Otorhinolaryngol. 2024;90:101353

  • The GCBI questionnaire in tonsillectomized children obtained a Cronbach's alpha of 0.94.

  • The translation of the GCBI questionnaire maintained semantic equivalence.

  • The cross-cultural adaptation of the GCBI is conceptually and culturally adequate for the sample.

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Alpha-lipoic acid does not improve olfactory training results in olfactory loss due to COVID-19: a double-blind randomized trial
Lorena Pinheiro Figueiredo, Paulo Victor dos Santos Lima Paim, Thiago Cerqueira-Silva, Carolina Cincurá Barreto, Marcus Miranda Lessa
Braz J Otorhinolaryngol. 2024;90:101356

  • Alpha-lipoic acid is not better than olfactory training alone after COVID-19.

  • We found a strongly difference in baseline and endline olfaction in both groups.

  • This is the first trial comparing alpha-lipoic acid as an adjuvant treatment.

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miR-186 regulates epithelial–mesenchymal transformation to promote nasopharyngeal carcinoma metastasis by targeting ZEB1
Liangke Tang, Yalang Xiang, Jing Zhou, Tao Li, Tingting Jia, Guobo Du
Braz J Otorhinolaryngol. 2024;90:101358

  • MiR-186 was lowly expressed in nasopharyngeal carcinoma.

  • MiR-186 inhibited epithelial–mesenchymal transformation of nasopharyngeal carcinoma.

  • MiR-186 directly targets ZEB1 to negatively regulate its expression.

  • MiR-186 regulated the epithelial–mesenchymal transformation by targeting ZEB1.

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Audiometric evaluation in different clinical presentations of otitis media
Ana Luiza Papi Kasemodel de Araújo, Francisco Polanski Cordeiro, Rafael da Costa Monsanto, Norma de Oliveira Penido
Braz J Otorhinolaryngol. 2024;90:101359

  • Otitis a common disease with several complications, specially hearing loss.

  • There is no previous study comparing hearing in different presentations of otitis.

  • We observed sequelae in the various groups, even in acute cases after resolution.

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Hsa_circ_0013561 promotes progression of nasopharyngeal carcinoma by activating JAK2/STAT3 signaling pathway
Tian Kaisai, Zheng Mantang, Yuan Tailei, Zheng Liying, Chen Xiaoping, Jin Mingming, Zhang Yi
Braz J Otorhinolaryngol. 2024;90:101362

  • Hsa_circ_0013561 is significantly up regulated in nasopharyngeal carcinoma.

  • Knockdown of Hsa_circ_0013561 in NPC cells inhibited cell proliferation and migration.

  • Knockdown of Hsa_circ_0013561 in NPC cells inhibited EMT progression in vitro.

  • Hsa_circ_0013561 functions through the JAK2/STAT3 signaling pathway.

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Effectiveness and tolerance of electrochemotherapy as palliative therapy for patients with head and neck cancer and malignant melanoma and its relation to early skin reaction
Miguel Caballero-Borrego, Sandra Coll, Pilar Navarrete
Braz J Otorhinolaryngol. 2024;90:101365

  • Electrochemotherapy treatment is a well tolerate procedure.

  • Electrochemotherapy treatment is associated with a higher overall survival in patients with neck metastasis of squamous cell carcinoma.

  • Electrochemotherapy treatment is associated with a diminution of pain and anxiety in patients with neck metastasis.

  • Electrochemotherapy is an option as palliative treatment for patients with neck metastasis of carcinoma refractory to other therapies.

  • The type of healing (ulcer vs dry crust) of the surgical wound could not be associated with a higher rate of response or survival.

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The potential relationship between uric acid and the recovery in sudden sensorineural hearing loss
Yandan Zhou, Jie Wen, Zhongchun Yang, Ruifang Zeng, Wei Gong, Qiancheng Jing
Braz J Otorhinolaryngol. 2024;90:101368

  • Hyperuricemia is an independent risk factor for hearing recovery in SSNHL.

  • Serum uric acid levels negatively affect hearing outcome in SSNHL.

  • Initial hearing threshold is a risk factor for SSNHL recovery.

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Effect of butorphanol-soaked nasal packing after endoscopic nasal surgery: a double-blind, randomized, placebo-controlled trial
Jiamei He, Qingyu Xiao, Yu Shuai, Xiaoli Liu, Shaohui Zhuang
Braz J Otorhinolaryngol. 2024;90:101369

  • Butorphanol-soaked nasal packing can reduce pain and improve sleep quality.

  • Butorphanol-soaked nasal packing does not increase adverse effects after surgery.

  • 0.03mg/kg butorphanol may be more appropriate for clinical use than 0.04mg/kg.

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Review articles
Does a patient with acquired arbovirus infection have a hearing impairment? A scoping review of hearing changes in an adult with Dengue, Chikungunya, and Zika
Leonardo Gleygson Angelo Venâncio, Lilian Ferreira Muniz, Lais Cristine Delgado da Hora, Jéssica Dayane da Silva, Gabriela Silva Teixeira Cavalcanti, Mariana de Carvalho Leal, Sílvio da Silva Caldas Neto
Braz J Otorhinolaryngol. 2024;90:101342

  • Hearing alteration may occur during Dengue, Chikungunya, and Zika infections.

  • Otalgia, hypoacusis, vertigo and tinnitus were the most common symptoms.

  • Sensorineural hearing loss was more notiaceable in adults exposed to Zika virus.

  • The actual effect of arboviruses on hearing from adults is unknown.

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Auditory training for tinnitus treatment: a scoping review
Anna Carolina Marques Perrella de Barros, Rhayane Vitória Lopes, Daniela Gil, Andreia Cristina Feitosa do Carmo, Ektor Tsuneo Onishi, Fátima Cristina Alves Branco-Barreiro
Braz J Otorhinolaryngol. 2024;90:101361

  • Auditory training for tinnitus is studied as an auditory rehabilitation strategy.

  • There is still no consensus on the best practice methodology.

  • There is a need for further high-level studies in this area.

  • Auditory discrimination training was the most studied type.

  • Considering attentional factors and multisensory paths may lead to future research.

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Case reports
Human immunodeficiency virus-positive patients with parotid gland disease referred for otolaryngology consultation: a case series
Toshiyuki Akama, Takeshi Tsuda, Kazuya Takeda, Hiroshi Nishimura
Braz J Otorhinolaryngol. 2024;90:101339
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Ossifying hemangioma of the frontal sinus: a case report
Changxing Cao, Shasha Guo, Qiulin Liang, Chao Feng, Maomei Ni, Feng Zhou, Huiping Ye
Braz J Otorhinolaryngol. 2024;90:101341
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Cartilaginous choristoma in the external auditory canal
Junhui Jeong, Mi Jang
Braz J Otorhinolaryngol. 2024;90:101344
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Bilateral epidermoid vocal cysts. Case report
Regina Helena Garcia Martins, Claudia Mendonça Xavier, Alessandra Loli, Lucas Yamada Kurosaki, Elaine Lara Mendes Tavares, Andrea Joia Gramuglia
Braz J Otorhinolaryngol. 2024;90:101357
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Brazilian Journal of Otorhinolaryngology (English Edition)
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Articles submitted as of May 1, 2022, which are accepted for publication will be subject to a fee (Article Publishing Charge, APC) payment by the author or research funder to cover the costs associated with publication. By submitting the manuscript to this journal, the authors agree to these terms. All manuscripts must be submitted in English.. Os artigos submetidos a partir de 1º de maio de 2022, que forem aceitos para publicação estarão sujeitos a uma taxa (Article Publishing Charge, APC) a ser paga pelo autor para cobrir os custos associados à publicação. Ao submeterem o manuscrito a esta revista, os autores concordam com esses termos. Todos os manuscritos devem ser submetidos em inglês.